Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells.

Chemico-biological interactions - 1 Apr 2024

Chee Cheok Wui, Mohd Hashim Najihah, Nor Rashid Nurshamimi

Abstract excerpt

There is an increasing demand for anticancer agent in treating colorectal cancer (CRC) with frequently mutated TP53 and KRAS genes. Phytochemical compounds are suitable as chemoprevention for CRC since dietary factor is a major risk factor. Anthraquinones from Morinda citrifolia L. were previously reported with various pharmacological properties. Various in vitro experiments were conducted to investigate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthraquinones
Share to Cell Proliferation
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Proto-Oncogene Proteins p21(ras)

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 38423379
DOI: 10.1016/j.cbi.2024.110928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells.PMID 38423379Read ↗

A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on molecular and biochemical processesSemantic proximity Read ↗

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cellsSemantic proximity Read ↗

Natural products for treating colorectal cancer: A mechanistic reviewSemantic proximity Read ↗

Screening of a FDA-Approved Compound Library Identifies Menadione in Regulating Colon Cancer Programmed Death via MAPK8 CascadesSemantic proximity Read ↗

Characterization of novel natural compound derivatives with cancer-selective cytotoxicitySemantic proximity Read ↗

Antiproliferative and Apoptotic Effects of Red Beetroot and Betanin on Human Colorectal Cancer Cell LinesSemantic proximity Read ↗

Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanismSemantic proximity Read ↗

KRAS Mutation Reduces Thymoquinone Anticancer Effects on Viability of Cells and Apoptosis.Semantic proximity Read ↗

Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular PathwaysSemantic proximity Read ↗

Targeting Oncogenic Mutations in Colorectal Cancer using CryptotanshinoneSemantic proximity Read ↗

The Mechanism of Aloe-emodin in the Treatment of Colon Cancer based on Network Pharmacological AnalysisSemantic proximity Read ↗

Saffron and Its Major Ingredients’ Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite InstabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.