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Article

P53-regulated autophagy and its impact on drug resistance and cell fate

1 Jan 2021

Abstract excerpt

Wild-type p53 is a stress-responsive transcription factor and a potent tumor suppressor. P53 inhibits the growth of incipient cancer cells by blocking their proliferation or inducing their death through apoptosis. Autophagy is a self-eating process that plays a key role in response to stress. During autophagy, organelles and other intracellular components are degraded in autophagolysosomes and the autophagic...

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PMID: 34532654
DOI: 10.20517/cdr.2020.85

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