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Article

The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment.

PloS one - 1 Jan 2012

Li Dan-Dan, Sun Ting, Wu Xiao-Qi, Chen Shu-Peng, Deng Rong, Jiang Shan, Feng Gong-Kan, Pan Jing-Xuan, Zhang Xiao-Shi, Zeng Yi-Xin, Zhu Xiao-Feng

Abstract excerpt

BACKGROUND: Topotecan produces DNA damage that induces autophagy in cancer cells. In this study, sensitising topotecan to colon cancer cells with different P53 status via modulation of autophagy was examined. METHODOLOGY/PRINCIPAL FINDINGS: The DNA damage induced by topotecan treatment resulted in cytoprotective autophagy in colon cancer cells with wild-type p53. However, in cells with mutant p53 or p53 knockout,...

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Identifiers

PMID: 23024792
DOI: 10.1371/journal.pone.0045058
PMCID: PMC3443203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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