Article
Single Marker Family-Based Association Analysis Not Conditional on Parental Information.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Namkung Junghyun, Won Sungho
Abstract excerpt
Family-based association analysis unconditional on parental genotypes models the effects of observed genotypes. This approach has been shown to have greater power than conditional methods. In this chapter, we review popular association analysis methods accounting for familial correlations: the marginal model using generalized estimating equations (GEE), the mixed model with a polygenic random component, and...
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