A machine-learning heuristic to improve gene score prediction of polygenic traits

Abstract excerpt

Abstract Machine-learning techniques have helped solve a broad range of prediction problems, yet are not widely used to build polygenic risk scores for the prediction of complex traits. We propose a novel heuristic based on machine-learning techniques (GraBLD) to boost the predictive performance of polygenic risk scores. Gradient boosted regression trees were first used to optimize the weights of SNPs included in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Associations and Epidemiology
• Share to Genetic Syndromes and Imprinting
• Share to Liver Disease Diagnosis and Treatment