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Article

Meta-analysis of Randomized Controlled Trials of Genotype-Guided vs Standard Dosing of Warfarin.

Chest - 1 Sept 2015

Dahal Khagendra, Sharma Sharan P, Fung Erik, Lee Juyong, Moore Jason H, Unterborn John N, Williams Scott M

Abstract excerpt

BACKGROUND: Warfarin is a widely prescribed anticoagulant, and its effect depends on various patient factors including genotypes. Randomized controlled trials (RCTs) comparing genotype-guided dosing (GD) of warfarin with standard dosing have shown mixed efficacy and safety outcomes. We performed a meta-analysis of all published RCTs comparing GD vs standard dosing in adult patients with various indications of...

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Identifiers

PMID: 25811981
DOI: 10.1378/chest.14-2947
PMCID: PMC4556123

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TTR

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