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Article

Aryl Hydrocarbon Receptor Ablation in Cardiomyocytes Protects Male Mice From Heart Dysfunction Induced by NKX2.5 Haploinsufficiency.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2017

Wang Qin, Fan Yunxia, Kurita Hisaka, Jiang Min, Koch Sheryl, Rao Marepalli B, Rubinstein Jack, Puga Alvaro

Abstract excerpt

Epidemiological studies in humans and research in vertebrates indicates that developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a ubiquitous and biopersistent environmental toxicant, is associated with incidence of early congenital heart disease in the embryo and later in the adult. TCDD-mediated toxicity depends on the aryl hydrocarbon receptor (AHR) but the role of the TCDD-activated AHR in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Homeobox Protein Nkx-2.5

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Source

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Identifiers

PMID: 28973413
DOI: 10.1093/toxsci/kfx164
PMCID: PMC5837197

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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