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Article

PCB126 exposure disrupts zebrafish ventricular and branchial but not early neural crest development.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2008

Grimes Adrian C, Erwin Kyle N, Stadt Harriett A, Hunter Ginger L, Gefroh Holly A, Tsai Huai-Jen, Kirby Margaret L

Abstract excerpt

We have used zebrafish and 3,3',4,4',5-pentachlorobiphenyl (PCB126) to investigate the developmental toxicity of polychlorinated biphenyls (PCBs) that exert their effects through the aryl hydrocarbon receptor (AHR). We found that cardiac and neural crest (NC)-derived jaw and branchial cartilages are specifically targeted early in development. The suite of malformations, which ultimately leads to circulatory...

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Identifiers

PMID: 18660518
DOI: 10.1093/toxsci/kfn154
PMCID: PMC2563148

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AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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