Article
SH-Alb inhibits phenotype remodeling of pro-fibrotic macrophage to attenuate liver fibrosis through SIRT3-SOD2 axis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2024
Wu Nijin, Ma Shujun, Ding Han, Cao Huiling, Liu Tiantian, Tian Miaomiao, Liu Qiqi, Bian Hongjun, Yu Zhen, Liu Chenxi, Wang Le, Feng Yuemin, Wu Hao, Qi Jianni
Abstract excerpt
Albumin has a variety of biological functions, such as immunomodulatory and antioxidant activity, which depends largely on its thiol activity. However, in clinical trials, the treatment of albumin by injection of commercial human serum albumin (HSA) did not achieve the desired results. Here, we constructed reduced modified albumin (SH-Alb) for in vivo and in vitro experiments to investigate the reasons why HSA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.