Article
Novel miR-b2122 regulates several ALS-related RNA-binding proteins.
Molecular brain - 2 Oct 2017
Hawley Zachary C E, Campos-Melo Danae, Strong Michael J
Abstract excerpt
Common pathological features of amyotrophic lateral sclerosis (ALS) include cytoplasmic aggregation of several RNA-binding proteins. Out of these RNA-binding proteins, TDP-43, FUS/TLS and RGNEF have been shown to co-aggregate with one another within motor neurons of sporadic ALS (sALS) patients, suggesting that there may be a common regulatory network disrupted. MiRNAs have been a recent focus in ALS research as...
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