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Article

Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS.

Cellular and molecular life sciences : CMLS - 1 Dec 2018

Helferich Anika M, Brockmann Sarah J, Reinders Jörg, Deshpande Dhruva, Holzmann Karlheinz, Brenner David, Andersen Peter M, Petri Susanne, Thal Dietmar R, Michaelis Jens, Otto Markus, Just Steffen, Ludolph Albert C, Danzer Karin M, Freischmidt Axel, Weishaupt Jochen H

Abstract excerpt

Genetic and functional studies suggest diverse pathways being affected in the neurodegenerative disease amyotrophic lateral sclerosis (ALS), while knowledge about converging disease mechanisms is rare. We detected a downregulation of microRNA-1825 in CNS and extra-CNS system organs of both sporadic (sALS) and familial ALS (fALS) patients. Combined transcriptomic and proteomic analysis revealed that reduced levels...

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Identifiers

PMID: 30030593
DOI: 10.1007/s00018-018-2873-1
PMCID: PMC11105367

Genes

TBCB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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