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Article

Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function

8 Apr 2015

Abstract excerpt

Epithelial-mesenchymal transition (EMT) in cells is a developmental process adopted during tumorigenesis that promotes metastatic capacity. In this study, we advance understanding of EMT control in cancer cells with the description of a novel vimentin-ERK axis that regulates the transcriptional activity of Slug (SNAI2). Vimentin, ERK, and Slug exhibited overlapping subcellular localization in clinical specimens...

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PMID: 25855378
DOI: 10.1158/0008-5472.can-14-2842

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