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Article

ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema.

Pulmonary pharmacology & therapeutics - 1 Feb 2018

Nojiri Masafumi, Mizuno Shiro, Nishiki Kazuaki, Kato Ryo, Nakagawa Ken, Oikawa Taku, Iguchi Masaharu, Osanai Kazuhiro, Ishizaki Takeshi, Toga Hirohisa

Abstract excerpt

BACKGROUND: Genetic variation in the β2-adrenergic receptor (ADRB2) gene has been thought to have an important role in the differential response to β2-agonist therapy for asthma. However, previous studies have shown little evidence for an association between these ADRB2 variants and the bronchial dilator response (BDR) in chronic obstructive pulmonary disease (COPD) patients. This discrepancy could be explained...

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Share to Aged, 80 and over
Share to Bronchodilator Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Share to Pulmonary Emphysema

Share to Receptors, Adrenergic, beta-2

Share to Tomography, X-Ray Computed

Source

Identifiers

PMID: 28964817
DOI: 10.1016/j.pupt.2017.09.004

Genes

ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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