Article
Variants of the ADRB2 Gene in COPD: Systematic Review and Meta-Analyses of Disease Risk and Treatment Response.
COPD - 1 Aug 2017
Nielsen Anne Orholm, Jensen Camilla Steen, Arredouani Mohamed Simo, Dahl Ronald, Dahl Morten
Abstract excerpt
The β2-adrenergic receptor (ADRB2) is an important regulator of airway smooth muscle tone in chronic obstructive pulmonary disease (COPD). Variants that impair ADRB2 function could increase disease risk or reduce the response to endogenous and inhaled adrenergic agonists in COPD. We performed a systematic review and three meta-analyses to assess whether three functional variants (Thr164Ile, Arg16Gly, and...
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