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Article

Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis.

The Journal of pathology - 1 Dec 2018

Liu Rong, Shi Peiguo, Zhou Zhongmei, Zhang Hailin, Li Wei, Zhang Hong, Chen Ceshi

Abstract excerpt

Krüpple-like factor 5 (KLF5) is required for the development of the embryo and multiple organs, such as the lung and intestine. KLF5 plays a pro-proliferative and oncogenic role in several carcinomas, including breast cancer. However, its role in normal mammary gland development and oncogenesis has not been elucidated in vivo. In this study, we used mammary gland-specific Klf5 conditional knockout mice derived by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30101462
DOI: 10.1002/path.5153

Genes

KLF5

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