Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Nov 2017

Praski Alzrigat Lisa, Huseby Douglas L, Brandis Gerrit, Hughes Diarmaid

Abstract excerpt

OBJECTIVES: To determine whether the spectrum of mutations in marR in ciprofloxacin-resistant clinical isolates of Escherichia coli shows evidence of selection bias, either to reduce fitness costs, or to increase drug resistance. MarR is a repressor protein that regulates, via MarA, expression of the Mar regulon, including the multidrug efflux pump AcrAB-TolC. METHODS: Isogenic strains carrying 36 different marR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ciprofloxacin
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli Infections

Share to Escherichia coli Proteins

Share to Genetic Fitness

Share to Multidrug Resistance-Associated Proteins

Share to Real-Time Polymerase Chain Reaction

Share to Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28962020
DOI: 10.1093/jac/dkx270
PMCID: PMC5890708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli.PMID 28962020Read ↗

Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli.Semantic proximity Read ↗

Identification for mar mutants among quinolone-resistant clinical isolates of Escherichia coli.Semantic proximity Read ↗

Chromosomal mutations that accompany qnr in clinical isolates of Escherichia coli.Semantic proximity Read ↗

Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.Semantic proximity Read ↗

Overexpression of RamA, Which Regulates Production of the Multidrug Resistance Efflux Pump AcrAB-TolC, Increases Mutation Rate and Influences Drug Resistance Phenotype.Semantic proximity Read ↗

Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.Semantic proximity Read ↗

Phenotypic changes associated with the fitness cost in antibiotic resistant Escherichia coli strains.Semantic proximity Read ↗

Upregulation of AcrEF in Quinolone Resistance Development in Escherichia coli When AcrAB-TolC Function Is Impaired.Semantic proximity Read ↗

Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli.Semantic proximity Read ↗

Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes.Semantic proximity Read ↗

Interplay in the selection of fluoroquinolone resistance and bacterial fitness.Semantic proximity Read ↗

Differential impact of ramRA mutations on both ramA transcription and decreased antimicrobial susceptibility in Salmonella Typhimurium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.