The influence of MIR137 on white matter fractional anisotropy and cortical surface area in individuals with familial risk for psychosis.

doi:10.1016/j.schres.2017.09.030

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Article

The influence of MIR137 on white matter fractional anisotropy and cortical surface area in individuals with familial risk for psychosis.

Schizophrenia research - 1 May 2018

Vogel Bob O, Lett Tristram A, Erk Susanne, Mohnke Sebastian, Wackerhagen Carolin, Brandl Eva J, Romanczuk-Seiferth Nina, Otto Kristina, Schweiger Janina I, Tost Heike, Nöthen Markus M, Rietschel Marcella, Degenhardt Franziska, Witt Stephanie H, Meyer-Lindenberg Andreas, Heinz Andreas, Walter Henrik

Abstract excerpt

The rs1625579 variant near the microRNA-137 (MIR137) gene is one of the best-supported schizophrenia variants in genome-wide association studies (GWAS), and microRNA-137 functionally regulates other GWAS identified schizophrenia risk variants. Schizophrenia patients with the MIR137 rs1625579 risk genotype (homozygous for the schizophrenia risk variant) also have aberrant brain structure. It is unclear if the...

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Anisotropy
Cerebral Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Frequency

Genome-Wide Association Study

MicroRNAs

Polymorphism, Single Nucleotide

Psychotic Disorders

White Matter

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PMID: 28958479
DOI: 10.1016/j.schres.2017.09.030

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