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Article

No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure.

Schizophrenia research - 1 Nov 2014

Cousijn Helena, Eissing Marc, Fernández Guillén, Fisher Simon E, Franke Barbara, Zwiers Marcel, Harrison Paul J, Arias-Vásquez Alejandro

Abstract excerpt

Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects--including the combined effect of the genes--nor single SNP...

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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Brain
Genome-Wide Association Study
Kruppel-Like Transcription Factors
MicroRNAs

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PMID: 25217366
DOI: 10.1016/j.schres.2014.08.007
PMCID: PMC4245712

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TCF4

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No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure.PMID 25217366Read ↗

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Common variation in ZNF804A (rs1344706) is not associated with brain morphometry in schizophrenia or healthy participants.Semantic proximity Read ↗

ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls.Semantic proximity Read ↗

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Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants.Semantic proximity Read ↗

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