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Article

Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2018

Cosgrove Donna, Mothersill David O, Whitton Laura, Harold Denise, Kelly Sinead, Holleran Laurena, Holland Jessica, Anney Richard, Richards Alex, Mantripragada Kiran, Owen Michael, O'Donovan Michael C, Gill Michael, Corvin Aiden, Morris Derek W, Donohoe Gary

Abstract excerpt

Multiple genome-wide association studies of schizophrenia have implicated genetic variants within the gene encoding microRNA-137. As risk variants within or regulated by MIR137 have been implicated in memory performance, we investigated the additive effects of schizophrenia-associated risk variants in genes empirically regulated by MIR137 on brain regions associated with memory function. A polygenic risk score...

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Brain
Genome-Wide Association Study
MicroRNAs
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuropsychological Tests

Psychotic Disorders

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PMID: 29418072
DOI: 10.1002/ajmg.b.32620

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