Article
The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia.
Molecular psychiatry - 1 Apr 2013
Lett T A, Chakravarty M M, Chakavarty M M, Felsky D, Brandl E J, Tiwari A K, Gonçalves V F, Rajji T K, Daskalakis Z J, Meltzer H Y, Lieberman J A, Lerch J P, Mulsant B H, Kennedy J L, Voineskos A N
Abstract excerpt
We examined the influence of the genome-wide significant schizophrenia risk variant rs1625579 near the microRNA (miRNA)-137 (MIR137) gene on well-established sources of phenotypic variability in schizophrenia: age-at-onset of psychosis and brain structure. We found that the MIR137 risk genotype strongly predicts an earlier age-at-onset of psychosis across four independently collected samples of patients with...
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