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An Indian butyrylcholinesterase variant L307P is not structurally stable: a molecular dynamics simulation study.

Chemico-biological interactions - 25 Mar 2013

David Swapna Merlin, Venkatesan Santhosh Kannan, Boopathy Rathanam

Abstract excerpt

The human butyrylcholinesterase (BChE) activity is less than 1% in the serum of silent variant individuals of Vysya community in India. They are homozygous for a point mutation at codon 307 (CTT → CCT) resulting in the substitution of leucine 307 by proline. The reason for the disappearance of the protein in the serum has not been explicated till date. Based on this background, we performed molecular dynamics...

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PMID: 23123771
DOI: 10.1016/j.cbi.2012.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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