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Article

Conformational flexibility decreased due to Y67F and F82H mutations in cytochrome c: molecular dynamics simulation studies.

Journal of molecular graphics & modelling - 1 Oct 2009

Singh Sarkkarai Raja, Prakash Subash, Vasu Veerapandy, Karunakaran Chandran

Abstract excerpt

Cytochrome c (cyt c), a mitochondrial protein, has dual functions in controlling both cellular energetic metabolism and apoptosis (programmed cell death). During apoptosis, cyt c (Fe(3+)) released into the cytosol initiates caspase activation leading to apoptosis. Since, X-ray crystallography gives only the static structure, we report here the dynamic behavior of holo and apo wild type (WT), Y67F and F82H mutant...

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Identifiers

PMID: 19720549
DOI: 10.1016/j.jmgm.2009.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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