Article
Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation.
Molecular biology and evolution - 1 Oct 2017
Xu Duo, Pavlidis Pavlos, Taskent Recep Ozgur, Alachiotis Nikolaos, Flanagan Colin, DeGiorgio Michael, Blekhman Ran, Ruhl Stefan, Gokcumen Omer
Abstract excerpt
One of the most abundant proteins in human saliva, mucin-7, is encoded by the MUC7 gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein. We recently documented the adaptive evolution of MUC7 subexonic copy number variation among primates. Yet, the evolution of MUC7 genetic variation in humans remained unexplored. Here, we found...
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