Article
Exome capture from saliva produces high quality genomic and metagenomic data.
BMC genomics - 4 Apr 2014
Kidd Jeffrey M, Sharpton Thomas J, Bobo Dean, Norman Paul J, Martin Alicia R, Carpenter Meredith L, Sikora Martin, Gignoux Christopher R, Nemat-Gorgani Neda, Adams Alexandra, Guadalupe Moraima, Guo Xiaosen, Feng Qiang, Li Yingrui, Liu Xiao, Parham Peter, Hoal Eileen G, Feldman Marcus W, Pollard Katherine S, Wall Jeffrey D, Bustamante Carlos D, Henn Brenna M
Abstract excerpt
BACKGROUND: Targeted capture of genomic regions reduces sequencing cost while generating higher coverage by allowing biomedical researchers to focus on specific loci of interest, such as exons. Targeted capture also has the potential to facilitate the generation of genomic data from DNA collected via saliva or buccal cells. DNA samples derived from these cell types tend to have a lower human DNA yield, may be...
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