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Article

CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.

Therapeutic drug monitoring - 1 Dec 2008

Crettol Séverine, Venetz Jean-Pierre, Fontana Massimiliano, Aubert John-David, Pascual Manuel, Eap Chin B

Abstract excerpt

Cyclosporine is a substrate of cytochrome P450 (CYP) 3A and of the transporter ABCB1, for which polymorphisms have been described. In particular, CYP3A5 *3/*3 genotype results in the absence of CYP3A5 activity, whereas CYP3A7 *1/*1C genotype results in high CYP3A7 expression in adults. Log-transformed dose-adjusted cyclosporine trough concentration and daily dose per weight were compared 1, 3, 6, and 12 months...

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Share to ATP Binding Cassette Transporter, Subfamily B

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Source

Identifiers

PMID: 18978522
DOI: 10.1097/FTD.0b013e31818a2a60

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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