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Article

IRF 7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis

26 Sept 2017

Abstract excerpt

OBJECTIVE: The aim of the current study was to evaluate if methylation status of CpG sites of interferon regulatory factor 7 (IRF7) promoter in peripheral blood mononuclear cells (PBMCs) of systemic sclerosis (SSc) patients is involved in pathogenesis of the disease. METHODS: PBMCs were isolated from whole blood of 50 SSc patients and 30 controls. After the extraction of total RNA and DNA contents from PBMCs,...

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PMID: 28952189
DOI: 10.1111/1756-185x.13175

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