Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma.

Cancer research - 15 Nov 2017

Matsumoto Tomonori, Takai Atsushi, Eso Yuji, Kinoshita Kazuo, Manabe Toshiaki, Seno Hiroshi, Chiba Tsutomu, Marusawa Hiroyuki

Abstract excerpt

Hepatocellular carcinoma (HCC) originates from regenerating liver cells with genetic alterations in chronically inflamed liver. Ductal cells and hepatocytes proliferate for liver regeneration, and proliferating ductal cells (PDC) derived from bile ductules have long been considered putative liver stem/progenitor cells and candidate cellular origins of HCC. The potential of PDC as tumor-originating cells, however,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bile Ducts, Intrahepatic
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cell Adhesion Molecule

Share to Hepatitis

Share to Hepatocytes

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Neoplastic Stem Cells

Source

Identifiers

PMID: 28951464
DOI: 10.1158/0008-5472.CAN-17-1800

Genes

PDC
CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma.PMID 28951464Read ↗

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor CellsSemantic proximity Read ↗

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartmentSemantic proximity Read ↗

Oncogenic driver genes and tumor microenvironment determine the type of liver cancerSemantic proximity Read ↗

EpCAM+ Liver Cancer Stem-Like Cells Exhibiting Autocrine Wnt Signaling Potentially Originate in Cirrhotic PatientsSemantic proximity Read ↗

Cholangiocarcinomas can originate from hepatocytes in miceSemantic proximity Read ↗

Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.Semantic proximity Read ↗

Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liverSemantic proximity Read ↗

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in miceSemantic proximity Read ↗

Lineage fate of ductular reactions in liver injury and carcinogenesisSemantic proximity Read ↗

Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In VitroSemantic proximity Read ↗

Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma.Semantic proximity Read ↗

Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.