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Article

Targeted next-generation sequencing for analyzing the genetic alterations in atypical adenomatous hyperplasia and adenocarcinoma in situ.

Journal of cancer research and clinical oncology - 1 Dec 2017

Xu Xuan, Li Na, Zhao Ruiying, Zhu Lei, Shao Jinchen, Zhang Jie

Abstract excerpt

PURPOSE: Atypical adenomatous hyperplasia (AAH) and adenocarcinoma in situ (AIS) have been defined as preinvasive pulmonary adenocarcinoma lesions according to the 2015 World Health Organization lung adenocarcinoma classification. We aimed to search for the most common gene mutations in patients with AAH and AIS and investigate the distinctions between the two groups at the molecular level. METHODS: We performed...

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Source

Identifiers

PMID: 28821955
DOI: 10.1007/s00432-017-2500-9

Genes

ALK
BRAF
EGFR
ERBB2
FGFR3
KRAS
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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