Article
The polymorphism L204F affects transport and membrane expression of the sodium-dependent organic anion transporter SOAT (SLC10A6).
The Journal of steroid biochemistry and molecular biology - 1 May 2018
Bakhaus Katharina, Fietz Daniela, Kliesch Sabine, Weidner Wolfgang, Bergmann Martin, Geyer Joachim
Abstract excerpt
Sodium-dependent organic anion transporter (SOAT) represents a membrane transporter specific for sulfated steroid hormones, which are supposed to participate in the regulation of reproductive processes. In man, SOAT shows predominant mRNA expression in the testis and here was localized to primary spermatocytes. SOAT mRNA expression is significantly downregulated in different disorders of spermatogenesis,...
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