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Does the FSHB c.-211G>T polymorphism impact Sertoli cell number and the spermatogenic potential in infertile patients?

Andrology - 1 Sept 2020

Schubert Maria, Kaldewey Sophie, Pérez Lanuza Lina, Krenz Henrike, Dugas Martin, Berres Sven, Kliesch Sabine, Wistuba Joachim, Gromoll Jörg

Abstract excerpt

BACKGROUND: A genetic variant within the FSHB gene can deviate FSH action on spermatogenesis. The c.-211G>T FSHB single nucleotide polymorphism impacts FSHB transcription and biosynthesis due to interference with the LHX3 transcription factor binding. This SNP was previously shown to be strongly associated with lowered testicular volume, reduced sperm counts, and decreased FSH levels in patients carrying one or...

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PMID: 32096339
DOI: 10.1111/andr.12777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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