Article
A single nucleotide polymorphism in SPATA17 may be a genetic risk factor for Japanese patients with meiotic arrest.
Asian journal of andrology - 1 Sept 2009
Miyamoto Toshinobu, Tsujimura Akira, Miyagawa Yasushi, Koh Eitetsu, Sakugawa Naoko, Miyakawa Hiroe, Sato Hisashi, Namiki Mikio, Okuyama Akihiko, Sengoku Kazuo
Abstract excerpt
Genetic mechanisms have been implicated as a cause of some cases of male infertility. Recently, 10 novel genes involved in human spermatogenesis were identified by microarray analysis of human testicular tissue. One of these is spermatogenesis-associated 17 (SPATA17). To investigate whether defects in the SPATA17 gene are associated with azoospermia due to meiotic arrest, a mutational analysis was conducted, in...
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