Article
Analysis of polymorphisms in the SRD5A2 gene and semen parameters in Estonian men.
Journal of andrology - 1 Jan 2000
Peters Maire, Saare Merli, Kaart Tanel, Haller-Kikkatalo Kadri, Lend Ave Kris, Punab Margus, Metspalu Andres, Salumets Andres
Abstract excerpt
Spermatogenesis is an androgen-dependent process and polymorphisms in genes encoding androgen-metabolizing enzymes may be associated with impaired male fertility. The enzyme steroid 5α-reductase converts testosterone into dihydrotestosterone. We analyzed genotype frequencies of 5 single-nucleotide polymorphisms (SNPs 1-5) (rs632148, rs523349, rs2300701, rs2268797, and rs12470143) in the steroid 5α-reductase type...
