Article
Hippo Reprograms the Transcriptional Response to Ras Signaling.
Developmental cell - 25 Sept 2017
Pascual Justine, Jacobs Jelle, Sansores-Garcia Leticia, Natarajan Malini, Zeitlinger Julia, Aerts Stein, Halder Georg, Hamaratoglu Fisun
Abstract excerpt
Hyperactivating mutations in Ras signaling are hallmarks of carcinomas. Ras signaling mediates cell fate decisions as well as proliferation during development. It is not known what dictates whether Ras signaling drives differentiation versus proliferation. Here we show that the Hippo pathway is critical for this decision. Loss of Hippo switches Ras activation from promoting cellular differentiation to aggressive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.