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Article

IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan.

Cancer science - 1 Oct 2011

Yang Yung-Li, Hung Chia-Cheng, Chen Jiann-Shiuh, Lin Kai-Hsin, Jou Shiann-Tarng, Hsiao Chih-Cheng, Sheen Jiunn-Ming, Cheng Chao-Neng, Wu Kang-Hsi, Lin Shu-Rung, Yu Sung-Liang, Chen Hsuan-Yu, Lu Meng-Yao, Wang Shih-Chung, Chang Hsiu-Hao, Lin Shu-Wha, Su Yi-Ning, Lin Dong-Tsamn

Abstract excerpt

Despite current risk-directed therapy, approximately 15-20% of pediatric patients with acute lymphoblastic leukemia (ALL) have relapses. Recent genome-wide analyses have identified that an alteration of IKZF1 is associated with very poor outcomes in B-cell progenitor ALL. In this study, we determined the prognostic significance of IKZF1 deletions in patients with childhood ALL. This study analyzed 242 pediatric...

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Identifiers

PMID: 21740479
DOI: 10.1111/j.1349-7006.2011.02031.x
PMCID: PMC11159039

Genes

IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan.PMID 21740479Read ↗

Quantitative analysis of IKZF1 gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia: Higher levels are associated with a poorer prognosisSemantic proximity Read ↗

Quantitative analysis of IKZF1 gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia: Higher levels are associated with a poorer prognosisSemantic proximity Read ↗

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Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative StudySemantic proximity Read ↗

Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.Semantic proximity Read ↗

IKZF1plus is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemiaSemantic proximity Read ↗

IKZF1 Gene in Childhood B-cell Precursor Acute Lymphoblastic Leukemia: Interplay between Genetic Susceptibility and Somatic Abnormalities.Semantic proximity Read ↗

IKZF1 alterations and expression of CRLF2 predict prognosis in adult Chinese patients with B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

IKZF1andCRLF2gene alterations correlate with poor prognosis in JapaneseBCR‐ABL1‐negative high‐risk B‐cell precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

IKZF1 alterations in acute lymphoblastic leukemia: The good, the bad and the ugly.Semantic proximity Read ↗

Association of IKZF1 and CDKN2A gene polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis.Semantic proximity Read ↗

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