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Article

High frequency of IKZF1 genetic alterations in adult patients with B-cell acute lymphoblastic leukemia.

European journal of haematology - 1 Sept 2013

Tokunaga Kenji, Yamaguchi Shunichiro, Iwanaga Eisaku, Nanri Tomoko, Shimomura Taizo, Suzushima Hitoshi, Mitsuya Hiroaki, Asou Norio

Abstract excerpt

Alterations in the IKZF1 gene are associated with poor prognosis in pediatric B-cell acute lymphoblastic leukemia (B-ALL). We examined the relationship between IKZF1 alterations and clinical findings in 78 adult patients with B-ALL. Aberrant isoforms of IKZF1 were detected using RT-PCR. The copy numbers of IKZF1 exons and fusion genes caused by exon deletions were determined using RQ-PCR and genomic PCR,...

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Identifiers

PMID: 23751147
DOI: 10.1111/ejh.12155

Genes

IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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