[Impact of modification of cleavage site of fusion protein and foreign gene insertion on the virulence of Newcastle Disease Virus LaSota vaccine strain].

Abstract excerpt

Newcastle disease virus (NDV) cause a highly contagious and economically loss in poultry. The amino acid sequence at the protease cleavage site of the fusion (F) protein has been postulated as a major determinant of NDV virulence. In this study, we have examined the role of F protein cleavage site sequence in NDV virulence by use reverse genetics technology. The sequence G-R-Q-G-R-L present at the cleavage site...

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