Two single amino acid substitutions in the intervening region of Newcastle disease virus HN protein attenuate viral replication and pathogenicity.

doi:10.1038/srep13038

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Article

Two single amino acid substitutions in the intervening region of Newcastle disease virus HN protein attenuate viral replication and pathogenicity.

Scientific reports - 12 Aug 2015

Liu Bin, Ji Yanhong, Lin Zhongqing, Fu Yuguang, Muhammad Dafallah Rihab, Zhu Qiyun

Abstract excerpt

Among the proteins encoded by Newcastle disease virus (NDV), the attachment protein (HN) is an important determinant of virulence and pathogenicity. HN has been molecularly characterized at the protein level; however, the relationship between the molecular character of HN and the animal pathotype...

Topics

Amino Acid Substitution
Animals
Chickens
Genotype
HN Protein
Newcastle Disease
Newcastle disease virus
Virus Replication

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