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Article

Impact of the CYP2D6 ultrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers.

Journal of clinical psychopharmacology - 1 Dec 2004

Kirchheiner Julia, Henckel Hanns-Benjamin, Meineke Ingolf, Roots Ivar, Brockmöller Jürgen

Abstract excerpt

INTRODUCTION: In vitro studies showed that biotransformation of the antidepressant drug mirtazapine is mediated by cytochrome P-450 enzymes CYP1A2, CYP2D6, and CYP3A4 with CYP2D6 contributing about 35% to total mirtazapine biotransformation. We hypothesized that ultrarapid metabolizers (defined as carriers of the CYP2D6 gene duplication plus another functional allele) have a risk for therapeutic failure due to...

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Identifiers

PMID: 15538128
DOI: 10.1097/01.jcp.0000145341.30547.f0

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