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Article

Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.

Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2018

Tan Qiumin, Brunetti Lorenzo, Rousseaux Maxime W C, Lu Hsiang-Chih, Wan Ying-Wooi, Revelli Jean-Pierre, Liu Zhandong, Goodell Margaret A, Zoghbi Huda Y

Abstract excerpt

Capicua (CIC) regulates a transcriptional network downstream of the RAS/MAPK signaling cascade. In Drosophila, CIC is important for many developmental processes, including embryonic patterning and specification of wing veins. In humans, CIC has been implicated in neurological diseases, including spinocerebellar ataxia type 1 (SCA1) and a neurodevelopmental syndrome. Additionally, we and others have reported...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-myc

Share to ras Proteins

Share to Receptor, Notch1

Share to Repressor Proteins

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Source

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Identifiers

PMID: 29382756
DOI: 10.1073/pnas.1716452115
PMCID: PMC5816173

Genes

CIC
MYC
NOTCH1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.PMID 29382756Read ↗

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.Semantic proximity Read ↗

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancerSemantic proximity Read ↗

Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factorsSemantic proximity Read ↗

Comparative transcriptome analysis of isogenic cell line models and primary cancers links capicua ( CIC ) loss to activation of the MAPK signalling cascadeSemantic proximity Read ↗

The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations.Semantic proximity Read ↗

Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice.Semantic proximity Read ↗

Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.Semantic proximity Read ↗

Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse modelsSemantic proximity Read ↗

Multi-omic analysis of CIC’s functional networks reveals novel interaction partners and a potential role in mitotic fidelitySemantic proximity Read ↗

Parallel imaging of Drosophila embryos for quantitative analysis of genetic perturbations of the Ras pathway.Semantic proximity Read ↗

Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse modelsSemantic proximity Read ↗

Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALLSemantic proximity Read ↗

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