Article
Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations.
Gynecologic oncology - 1 Nov 2006
Cai Kathy Qi, Klein-Szanto Andres, Karthik Devarajan, Edelson Mitchell, Daly Mary B, Ozols Robert F, Lynch Henry T, Godwin Andrew K, Xu Xiang-Xi
Abstract excerpt
OBJECTIVE: From analysis of pre-cancer ovarian tissues obtained from prophylactic oophorectomies, several studies reported the increased ovarian morphological changes in high-risk ovaries, but whether these morphological changes are associated with BRCA1/BRCA2 genotypes or are cancer precursors i...
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