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Article

Susceptibility of Brca1 ( L63X/+ ) rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer

3 Feb 2025

Abstract excerpt

Abstract BRCA1 is one of the causative genes for hereditary breast and ovarian cancer syndrome with a high risk of early‐onset breast cancer. Whereas olaparib (OLA), an inhibitor of poly‐ADP‐ribose polymerase, has been applied as adjuvant therapy to those cancer patients, its effect on ovarian reproductive function remains unelucidated. Recently, a rat model (MUT; Brca1 (L63X/+) mutation) mimicking a human BRCA1...

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PMID: 39901592
DOI: 10.1111/cas.16412

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