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Article

Ovarian follicular density in women with BRCA1 and BRCA2 mutations: new insights into the negative impact on ovarian reserve.

Journal of ovarian research - 7 Feb 2026

Maletta Manuela, Vicenti Rossella, Forastiere Cristian, Di Santo Sara, Doglioli Marisol, Lenzi Jacopo, Raffone Antonio, Cobellis Luigi, Perandini Alessio, Somigliana Edgardo, Seracchioli Renato, Raimondo Diego

Abstract excerpt

BACKGROUND: Germline mutations of BRCA1 and BRCA2 may impair DNA repair in the ovarian cortex, leading to increased oocyte apoptosis, thus, affecting ovarian reserve. Aim of this study was to assess follicular density in ovarian biopsies from women with breast cancer carrying BRCA1 and BRCA2 mutations who underwent ovarian tissue cryopreservation (OTC) at our center. METHODS: This was a single center,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41654853
DOI: 10.1186/s13048-025-01901-1
PMCID: PMC12977439

Genes

BRCA1
BRCA2
OTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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