Resveratrol promotes bone mass in ovariectomized rats and the SIRT1 rs7896005 SNP is associated with bone mass in women during perimenopause and early postmenopause.

doi:10.1080/13697137.2022.2073809

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Article

Resveratrol promotes bone mass in ovariectomized rats and the SIRT1 rs7896005 SNP is associated with bone mass in women during perimenopause and early postmenopause.

Climacteric : the journal of the International Menopause Society - 1 Feb 2023

Wang X, Lu C, Chen Y, Wang Q, Bao X, Zhang Z, Huang X

Abstract excerpt

OBJECTIVE: This study aimed to examine the effects of SIRT1 agonist resveratrol on bone mass in ovariectomized (OVX) rats and the SIRT1 single-nucleotide polymorphism (SNP) rs7896005 on bone mass in women during menopause and early postmenopause. METHODS: An animal experiment was conducted on rats that were sham-operated (SHAM), OVX or OVX and different administered doses of resveratrol. Serum markers and femur...

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PMID: 35674253
DOI: 10.1080/13697137.2022.2073809

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