Article
Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells.
Metallomics : integrated biometal science - 18 Oct 2017
Schlottmann F, Vera-Aviles M, Latunde-Dada G O
Abstract excerpt
Dietary non-heme ferric iron is reduced by the ferric reductase enzyme, duodenal cytochrome b (Dcytb), before absorption by the divalent metal transporter 1 (DMT1). A single nucleotide polymorphism (SNP rs10455 mutant) that is located in the last exon of the Dcytb gene was reported in C282Y haemochromatosis HFE subjects. The present work therefore investigated the phenotype of this mutant Dcytb in Chinese hamster...
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