Article
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.
Blood - 15 Oct 2005
Gunshin Hiromi, Starr Carolyn N, Direnzo Cristina, Fleming Mark D, Jin Jie, Greer Eric L, Sellers Vera M, Galica Stephanie M, Andrews Nancy C
Abstract excerpt
Mammalian nonheme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine. This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells. To test its importance in vivo, we inactivated the murine Cybrd1 gene and assessed tissue iron stores in Cybrd1-null...
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