Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity.

doi:10.1093/infdis/jix334

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Article

Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity.

The Journal of infectious diseases - 15 Aug 2017

Agrawal Sonia, Moser Kara A, Morton Lindsay, Cummings Michael P, Parihar Ankita, Dwivedi Ankit, Shetty Amol C, Drabek Elliott F, Jacob Christopher G, Henrich Philipp P, Parobek Christian M, Jongsakul Krisada, Huy Rekol, Spring Michele D, Lanteri Charlotte A, Chaorattanakawee Suwanna, Lon Chanthap, Fukuda Mark M, Saunders David L, Fidock David A, Lin Jessica T, Juliano Jonathan J, Plowe Christopher V, Silva Joana C, Takala-Harrison Shannon

Abstract excerpt

Background: Amplified copy number in the plasmepsin II/III genes within Plasmodium falciparum has been associated with decreased sensitivity to piperaquine. To examine this association and test whether additional loci might also contribute, we performed a genome-wide association study of ex vivo P. falciparum susceptibility to piperaquine. Methods: Plasmodium falciparum DNA from 183 samples collected primarily...

Topics

Artemisinins
Aspartic Acid Endopeptidases
Cambodia
DNA Copy Number Variations
DNA, Protozoan
Drug Resistance
Genetic Loci
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotyping Techniques

Humans

Inhibitory Concentration 50

Linkage Disequilibrium

Membrane Transport Proteins

Mutation

Plasmodium falciparum

Polymorphism, Single Nucleotide

Proportional Hazards Models

Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28931241
DOI: 10.1093/infdis/jix334
PMCID: PMC5853219

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