Article
Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1.
Cell reports - 19 Sept 2017
Bagati Archis, Bianchi-Smiraglia Anna, Moparthy Sudha, Kolesnikova Kateryna, Fink Emily E, Lipchick Brittany C, Kolesnikova Masha, Jowdy Peter, Polechetti Anthony, Mahpour Amin, Ross Jason, Wawrzyniak Joseph A, Yun Dong Hyun, Paragh Gyorgy, Kozlova Nadezhda I, Berman Albert E, Wang Jianmin, Liu Song, Nemeth Michael J, Nikiforov Mikhail A
Abstract excerpt
Lineage-specific regulation of tumor progression by the same transcription factor is understudied. We find that levels of the FOXQ1 transcription factor, an oncogene in carcinomas, are decreased during melanoma progression. Moreover, in contrast to carcinomas, FOXQ1 suppresses epithelial-to-mesenchymal transition, invasion, and metastasis in melanoma cells. We find that these lineage-specific functions of FOXQ1...
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