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Article

Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit.

The Journal of biological chemistry - 10 Nov 2017

Rahman Kazi, Mandalasi Msano, Zhao Peng, Sheikh M Osman, Taujale Rahil, Kim Hyun W, van der Wel Hanke, Matta Khushi, Kannan Natarajan, Glushka John N, Wells Lance, West Christopher M

Abstract excerpt

Skp1 is a subunit of the SCF (Skp1/Cullin 1/F-box protein) class of E3 ubiquitin ligases that are important for eukaryotic protein degradation. Unlike its animal counterparts, Skp1 from Toxoplasma gondii is hydroxylated by an O2-dependent prolyl-4-hydroxylase (PhyA), and the resulting hydroxyproline can subsequently be modified by a five-sugar chain. A similar modification is found in the social amoeba...

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Identifiers

PMID: 28928220
DOI: 10.1074/jbc.M117.809301
PMCID: PMC5682971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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