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Article

A Cell Cycle-Regulated <i>Toxoplasma</i> Deubiquitinase, TgOTUD3A, Targets Polyubiquitins with Specific Lysine Linkages

22 Jun 2016

Abstract excerpt

The contribution of ubiquitin-mediated mechanisms in the regulation of the Toxoplasma gondii cell cycle has remained largely unexplored. Here, we describe the functional characterization of a T. gondii deubiquitinase (TGGT1_258780) of the ovarian-tumor domain-containing (OTU) family, which, based on its structural homology to the human OTUD3 clade, has been designated TgOTUD3A. The TgOTUD3A protein is expressed...

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PMID: 27340699
DOI: 10.1128/msphere.00085-16

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