Article

Potential for the Terminal SKP1 Glycosyltransferase to Exert Non-Enzymatic Control of SKP1 in Toxoplasma gondii

2026-06-13

Abstract excerpt

The SKP1/CUL1/F-Box protein (SCF) family of E3 ubiquitin ligases is responsible for targeting multiple proteins for degradation by the 26S proteosome. Within the family, multiple F-box proteins (FBPs) associate with the SKP1 adaptor which in turn docks to CUL1. In the human parasite Toxoplasma gondii, SKP1 is subject to oxygen-dependent regulation. Under normoxic conditions, the prolyl hydroxylase PHYa hydroxylate...

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Literature Corpus work: 8cd194b7-d932-5c78-bf85-80025fbf52f8
DOI: 10.64898/2026.06.11.731712

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